Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955039 | 0.79 | ALPL (0.54) | ALPLDGAT1PDE4APDE4BPDE4C | |
| SCHEMBL17450629 | 0.79 | DGAT1 (0.47) | ALPLDGAT1PDGFRBKDRCYP11B1 | |
| SCHEMBL3676643 | 0.77 | ALPL (0.46) | ALPLDGAT1PDGFRBKDRAAK1 | |
| SCHEMBL455653 | 0.75 | ALPL (0.46) | ALPLDGAT1PDGFRBKDRAAK1 | |
| SCHEMBL29556839 | 0.75 | ALPL (0.56) | ALPLPDGFRBKDR | |
| SCHEMBL790824 | 0.75 | ALPL (0.56) | ALPLPDGFRBKDR | |
| SCHEMBL9960814 | 0.74 | ALPL (0.58) | ALPLDGAT1PDGFRBKDRALDH1A1 | |
| SCHEMBL15056968 | 0.73 | AAK1 (0.44) | ALPLDGAT1PDGFRBKDRAAK1 | |
| SCHEMBL789432 | 0.73 | ALPL (0.52) | ALPLDGAT1MAPK1PDGFRBKDR | |
| SCHEMBL15956784 | 0.73 | DGAT1 (0.43) | ALPLDGAT1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |