Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960814 | 0.85 | ALPL (0.58) | ALPLALDH1A1KMT2ADGAT1KDM4E | |
| SCHEMBL9954248 | 0.83 | ALPL (0.54) | ALPLMAPTDGAT1PDGFRBKDR | |
| SCHEMBL9954091 | 0.81 | ALPL (0.61) | ALPLALDH1A1KMT2AMEN1DGAT1 | |
| SCHEMBL9954614 | 0.80 | ALPL (0.52) | ALPLDGAT1PDGFRBKDR | |
| SCHEMBL9953056 | 0.79 | ALPL (0.47) | ALPLALDH1A1MAPTDGAT1PDE4A | |
| SCHEMBL9954653 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTKMT2AMEN1 | |
| SCHEMBL798423 | 0.78 | ALPL (0.76) | ALPLALDH1A1KMT2APDGFRBKDR | |
| SCHEMBL9954690 | 0.77 | ALPL (0.57) | ALPLDGAT1PDGFRBKDR | |
| SCHEMBL17450629 | 0.76 | DGAT1 (0.47) | ALPLDGAT1PDGFRBKDR | |
| SCHEMBL1502534 | 0.76 | ALPL (0.56) | ALPLDGAT1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |