Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | PER2 | O15055 | 1/20 | 0.30 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.30 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11954378 | 0.80 | POLB (0.36) | ALDH1A1POLBCA2MAPTALOX15 | |
| SCHEMBL22757767 | 0.76 | POLB (0.34) | ALDH1A1POLBMAPTALOX15NQO2 | |
| SCHEMBL12707759 | 0.76 | POLB (0.34) | ALDH1A1POLBMAPTALOX15NQO2 | |
| SCHEMBL15491574 | 0.75 | PER2 (0.38) | ALDH1A1POLBCA2GRIA4PER2 | |
| SCHEMBL16272667 | 0.74 | POLB (0.33) | ALDH1A1POLBCA2MAPTALOX15 | |
| SCHEMBL17922093 | 0.74 | POLB (0.31) | POLB | |
| SCHEMBL1658968 | 0.73 | ALOX15 (0.38) | ALDH1A1POLBMAPTALOX15NQO2 | |
| SCHEMBL22481992 | 0.73 | POLB (0.35) | ALDH1A1POLBMAPTALOX15NQO2 | |
| SCHEMBL3043384 | 0.73 | POLB (0.44) | ALDH1A1POLBCA2MAPTALOX15 | |
| SCHEMBL6966087 | 0.71 | POLB (0.42) | ALDH1A1POLBCA2MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655362-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | Abbvie Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087833-A1 | HEPATITIS C INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2012-06-28 | — | — | WO | disclosed |