Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.44 |
| ▸ | CTSD | P07339 | 6/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31241110 | 1.00 | PDE5A (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31241042 | 0.85 | MAPK8 (0.47) | CACNA2D1MAPK8MEN1KMT2AATM | |
| SCHEMBL31241091 | 0.81 | CACNA2D1 (0.47) | CACNA2D1MEN1KMT2AATMALDH1A1 | |
| SCHEMBL20641274 | 0.81 | AURKA (0.47) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10289136 | 0.81 | CACNA2D1 (0.51) | CACNA2D1MEN1KMT2AATMHTT | |
| SCHEMBL10289135 | 0.80 | CTSD (0.48) | CACNA2D1CTSDALDH1A1HTT | |
| SCHEMBL9955787 | 0.78 | CTSD (0.47) | CACNA2D1CTSDALDH1A1HTT | |
| SCHEMBL9029528 | 0.77 | TP53 (0.47) | CACNA2D1MAPK8ATMALDH1A1 | |
| SCHEMBL9952969 | 0.77 | DPP4 (0.51) | CACNA2D1MEN1KMT2AATMDPP4 | |
| SCHEMBL10288755 | 0.77 | POLR1A (0.41) | CACNA2D1CTSDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |