Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953081 | 0.83 | NAMPT (0.37) | POLBSMN1; SMN2 | |
| SCHEMBL9953570 | 0.81 | LMNA (0.55) | POLBALDH1A1LMNAMAPK1MAPT | |
| SCHEMBL9952709 | 0.81 | SMN1; SMN2 (0.36) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL9955026 | 0.80 | TSHR (0.55) | POLBALDH1A1LMNAMAPK1NPSR1 | |
| SCHEMBL14305923 | 0.78 | SMN1; SMN2 (0.57) | POLBALDH1A1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL9955406 | 0.75 | GLA (0.42) | POLBSMN1; SMN2 | |
| SCHEMBL10289140 | 0.74 | KMT2A (0.44) | ALDH1A1LMNAMAPTHPGDKDM4E | |
| SCHEMBL9954692 | 0.73 | SHMT2 (0.42) | POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9954303 | 0.73 | PLA2G1B (0.41) | POLBSMN1; SMN2 | |
| SCHEMBL10289139 | 0.73 | GAA (0.55) | POLBALDH1A1NPSR1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |