Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953442 | 0.90 | KCNA5 (0.53) | POLBALDH1A1KCNA5SMN1; SMN2 | |
| SCHEMBL10153729 | 0.88 | MAPT (0.46) | POLBALDH1A1RAB9AKCNA5TSHR | |
| SCHEMBL30675135 | 0.88 | PRMT5 (0.47) | POLBPRMT5WDR77ALDH1A1SMN1; SMN2 | |
| SCHEMBL10154090 | 0.88 | KCNA5 (0.47) | ALDH1A1RAB9AKCNA5SMN1; SMN2 | |
| SCHEMBL10153615 | 0.85 | SCN9A (0.54) | POLBALDH1A1RAB9AKCNA5SMN1; SMN2 | |
| SCHEMBL9959336 | 0.84 | RAB9A (0.42) | POLBPRMT5WDR77ALDH1A1RAB9A | |
| SCHEMBL9959490 | 0.84 | PRMT5 (0.42) | POLBPRMT5WDR77ALDH1A1SMN1; SMN2 | |
| SCHEMBL29411937 | 0.84 | CNR1 (0.45) | POLBPRMT5WDR77ALDH1A1RAB9A | |
| SCHEMBL9959238 | 0.84 | ALDH1A1 (0.41) | POLBPRMT5WDR77ALDH1A1SMN1; SMN2 | |
| SCHEMBL30499662 | 0.84 | ALDH1A1 (0.41) | POLBPRMT5WDR77ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | claimed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |