Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959338 | 0.88 | KCNK3 (0.46) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL9952468 | 0.87 | ALDH1A1 (0.50) | RAB9APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL30675135 | 0.86 | PRMT5 (0.47) | POLBMEN1KMT2AALDH1A1PRMT5 | |
| SCHEMBL9958833 | 0.85 | ALDH1A1 (0.42) | RAB9APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9958767 | 0.85 | CNR1 (0.45) | RAB9APOLBALDH1A1PRMT5WDR77 | |
| SCHEMBL29411937 | 0.85 | CNR1 (0.45) | RAB9APOLBALDH1A1PRMT5WDR77 | |
| SCHEMBL9953409 | 0.84 | POLB (0.50) | RAB9APOLBALDH1A1TSHRPRMT5 | |
| SCHEMBL9958904 | 0.83 | PRMT5 (0.43) | MEN1KMT2APRMT5WDR77 | |
| SCHEMBL30089105 | 0.83 | KDR (0.47) | ALDH1A1PRMT5WDR77 | |
| SCHEMBL9952596 | 0.83 | KDR (0.47) | ALDH1A1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |