Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953825 | 0.87 | MAPT (0.48) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9953751 | 0.83 | KLKB1 (0.45) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9953332 | 0.81 | MAPT (0.46) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9953328 | 0.81 | MAPT (0.46) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9954127 | 0.81 | MAPT (0.46) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9955390 | 0.81 | MAPT (0.44) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9953974 | 0.80 | KLKB1 (0.45) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9953937 | 0.77 | MEN1 (0.46) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL9953429 | 0.77 | TP53 (0.45) | MAPTTHRBTP53LMNAMEN1 | |
| SCHEMBL9954480 | 0.77 | L3MBTL1 (0.46) | MAPTTHRBTP53LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |