Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.40 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.40 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954127 | 1.00 | MAPT (0.46) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9953332 | 1.00 | MAPT (0.46) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9953825 | 0.82 | MAPT (0.48) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9953451 | 0.81 | MAPT (0.44) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9953751 | 0.79 | KLKB1 (0.45) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9955390 | 0.77 | MAPT (0.44) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9953974 | 0.76 | KLKB1 (0.45) | MAPTTHRBMEN1KMT2ATSHR | |
| SCHEMBL9954292 | 0.73 | PTGS2 (0.49) | MAPTMEN1KMT2ACYP1A2RAB9A | |
| SCHEMBL9954555 | 0.73 | PTGS2 (0.49) | MAPTMEN1KMT2ACYP1A2RAB9A | |
| SCHEMBL9954289 | 0.73 | PTGS2 (0.49) | MAPTMEN1KMT2ACYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |