Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954949 | 0.84 | LMNA (0.39) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL9955960 | 0.79 | ALDH1A1 (0.59) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL8404510 | 0.79 | DYRK1A (0.54) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL9955574 | 0.76 | MEN1 (0.41) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL21596925 | 0.76 | DYRK1A (0.44) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL12330213 | 0.75 | ALDH1A1 (0.63) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL14943768 | 0.73 | ALDH1A1 (0.69) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL25174048 | 0.71 | IP6K1 (0.52) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL14041337 | 0.71 | KDM4E (0.38) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL10396461 | 0.71 | ALDH1A1 (0.66) | LMNAALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |