Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953480 | 0.84 | LMNA (0.47) | LMNAPARP1MAPTNPC1RAB9A | |
| SCHEMBL9955974 | 0.79 | ALDH1A1 (0.46) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8404501 | 0.79 | DYRK1A (0.42) | LMNACHEK1PARP1PIM1RPS6KA3 | |
| SCHEMBL23474002 | 0.72 | MAPT (0.42) | LMNAMAPTNPC1RAB9ANPSR1 | |
| SCHEMBL10396438 | 0.71 | ALDH1A1 (0.54) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7217441 | 0.70 | MAOA (0.44) | LMNAMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9595057 | 0.68 | NQO2 (0.50) | LMNAGRM2MAPTNPSR1ALDH1A1 | |
| SCHEMBL4499993 | 0.68 | MAPT (0.54) | LMNAMAPTNPC1RAB9AKDM4E | |
| SCHEMBL8404510 | 0.67 | DYRK1A (0.54) | LMNAPARP1MAPTNPC1RAB9A | |
| SCHEMBL9955960 | 0.67 | ALDH1A1 (0.59) | LMNAPARP1PIM1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |