Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.36 |
| ▸ | ACHE | P22303 | 5/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955960 | 0.79 | ALDH1A1 (0.59) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL9953480 | 0.76 | LMNA (0.47) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL5049374 | 0.68 | HTR3A (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11181374 | 0.68 | MPO (0.36) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL9955974 | 0.67 | ALDH1A1 (0.46) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL14686420 | 0.65 | MPO (0.43) | MEN1KMT2ACASP3 | |
| SCHEMBL5433753 | 0.64 | NT5E (0.46) | KDM4ELMNAPARP1BCHEACHE | |
| SCHEMBL858063 | 0.64 | PDE4A (0.53) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7124248 | 0.64 | ACHE (0.41) | KMT2AALDH1A1SMN1; SMN2ACHE | |
| SCHEMBL1991118 | 0.64 | BCHE (0.42) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |