Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953730 | 0.94 | ALPL (0.57) | ALPLPIK3CGPIK3C2GPIK3C3AAK1 | |
| SCHEMBL9954766 | 0.92 | ALPL (0.56) | ALPLPIK3CGPIK3C2GPIK3C3PIK3CA | |
| SCHEMBL9953817 | 0.92 | ALPL (0.56) | ALPLPIK3C3BRD4BRD3SMN1; SMN2 | |
| SCHEMBL9954287 | 0.91 | ALPL (0.55) | ALPLPIK3C3BRD4BRD3SMN1; SMN2 | |
| SCHEMBL21760716 | 0.89 | ALPL (0.53) | ALPLPIK3CGPIK3C2GPIK3C3PIK3CA | |
| SCHEMBL19303685 | 0.89 | ALPL (0.53) | ALPLPIK3CGPIK3C2GPIK3C3PIK3CA | |
| SCHEMBL14247601 | 0.85 | PIK3CD (0.40) | ALPLPIK3CGPIK3C3AAK1PIK3CD | |
| SCHEMBL23758152 | 0.84 | ALPL (0.49) | ALPLPIK3CGPIK3C2GPIK3C3AAK1 | |
| SCHEMBL9953472 | 0.81 | ALPL (0.62) | ALPLPIK3CGPIK3C3PIK3CAAAK1 | |
| SCHEMBL17394044 | 0.81 | L3MBTL1 (0.52) | L3MBTL1BRD4BRD3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |