Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | PRKCI | P41743 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925259 | 0.87 | MAPT (0.59) | HTTALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL10289025 | 0.84 | POLB (0.61) | HTTALDH1A1KDM4EGLASORT1 | |
| SCHEMBL6034144 | 0.83 | SORT1 (0.72) | ALDH1A1KDM4ESORT1KMT2ANPC1 | |
| SCHEMBL5925289 | 0.82 | KDM4E (0.51) | HTTALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL7516613 | 0.82 | HDAC1 (0.64) | HTTALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL26758014 | 0.79 | SMN1; SMN2 (0.76) | JAK2TYK2HTTALDH1A1GAA | |
| SCHEMBL14059394 | 0.79 | PRKCI (0.66) | HTTPRKCIALDH1A1ROCK2GAA | |
| SCHEMBL460200 | 0.78 | PRKCI (0.67) | JAK2TYK2HTTPRKCIALDH1A1 | |
| SCHEMBL30339468 | 0.78 | PRKCI (0.67) | JAK2TYK2HTTPRKCIALDH1A1 | |
| SCHEMBL14917439 | 0.78 | ROCK2 (0.66) | JAK2TYK2HTTPRKCIALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |