Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.66 |
| ▸ | PRKCI | P41743 | 3/20 | 0.58 |
| ▸ | TYK2 | P29597 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917461 | 0.90 | PRKCI (0.56) | ROCK2ROCK1PRKCITYK2JAK2 | |
| SCHEMBL14917435 | 0.85 | ALDH1A1 (0.61) | PRKCIKDM4EHTTALDH1A1 | |
| SCHEMBL30339468 | 0.83 | PRKCI (0.67) | PRKCITYK2JAK2HTTJAK1 | |
| SCHEMBL460200 | 0.83 | PRKCI (0.67) | PRKCITYK2JAK2HTTJAK1 | |
| SCHEMBL15140751 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1TYK2JAK2KDM4E | |
| Ammonia Solution, Strong SCHEMBL27706531 | 0.79 | GAA (0.50) | ROCK2ROCK1KDM4EL3MBTL1GAA | |
| SCHEMBL1232259 | 0.79 | GAA (0.50) | ROCK2ROCK1KDM4EL3MBTL1GAA | |
| SCHEMBL9954063 | 0.78 | JAK2 (0.54) | ROCK2ROCK1PRKCITYK2JAK2 | |
| SCHEMBL16713265 | 0.78 | CHRNB2 (0.55) | ROCK2ROCK1PRKCIKDM4EL3MBTL1 | |
| SCHEMBL14917446 | 0.76 | NPC1 (0.67) | KDM4ESMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | ROCK2 1485/4885ROCK1 849/4885PRKCI 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.