Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067101 | 0.86 | PIK3CD (0.42) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10288900 | 0.81 | IKBKB (0.39) | MAPTIKBKBKDM4ESMN1; SMN2SIRT6 | |
| SCHEMBL1771736 | 0.81 | MEN1 (0.38) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL21500091 | 0.80 | AAK1 (0.49) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29527107 | 0.80 | AAK1 (0.49) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15649386 | 0.77 | DEGS1 (0.47) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL29066252 | 0.76 | MAPT (0.37) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8125788 | 0.76 | NNMT (0.46) | MAPTKDM4ESIRT6ALDH1A1 | |
| SCHEMBL29527481 | 0.76 | L3MBTL1 (0.51) | NPC1RAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL114826 | 0.73 | PIK3CD (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |