SCHEMBL9954530

SCHEMBL9954530

Cc1cccc(-c2coc(Cl)n2)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 3/20 0.59
IDO1 P14902 1/20 0.44
METAP2 P50579 1/20 0.44
ATP4A P20648 2/20 0.42
ATP4B P51164 2/20 0.42
RAB9A P51151 4/20 0.42
NPC1 O15118 2/20 0.42
KDM4E B2RXH2 1/20 0.42
XDH P47989 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
KMO O15229 1/20 0.41
SCN9A Q15858 1/20 0.41
PBRM1 Q86U86 1/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10263343 0.82 ENPP3 (0.84) ENPP3IDO1METAP2RAB9ANPC1
SCHEMBL9955528 0.82 CYP19A1 (0.46) IDO1ATP4AATP4BRAB9ANPC1
SCHEMBL9954331 0.79 KDM4E (0.50) IDO1KDM4EBCHEACHEKMO
SCHEMBL3632196 0.79 CYP19A1 (0.48) ENPP3ATP4AATP4BRAB9ANPC1
SCHEMBL17922274 0.78 ENPP3 (0.65) ENPP3IDO1METAP2RAB9ANPC1
SCHEMBL3635042 0.77 MEN1 (0.48) ENPP3RAB9ANPC1KDM4ESMN1; SMN2
SCHEMBL27009164 0.77 ENPP3 (0.56) ENPP3IDO1METAP2ATP4AATP4B
SCHEMBL17922235 0.77 ENPP3 (0.56) ENPP3IDO1METAP2RAB9ANPC1
SCHEMBL9454811 0.76 ATP4A (0.56) ENPP3IDO1METAP2ATP4AATP4B
SCHEMBL3718120 0.74 ENPP3 (0.54) ENPP3RAB9ANPC1KDM4EXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012085857-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO disclosed
WO-2012085857-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO disclosed
WO-2012085852-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO disclosed
WO-2012085852-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO disclosed