Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337074 | 0.88 | PDE7A (0.63) | ALDH1A1PDE7ALMNASMN1; SMN2HCAR1 | |
| SCHEMBL9954589 | 0.82 | ALOX12 (0.50) | ALDH1A1ALOX12MDM2MAPTRAB9A | |
| SCHEMBL9954930 | 0.78 | POLB (0.58) | ALDH1A1PDE7ALMNASMN1; SMN2PDE4A | |
| SCHEMBL29832076 | 0.77 | PDE7A (0.66) | PDE7ALMNAHCAR1PDE4APDE4B | |
| SCHEMBL290297 | 0.77 | PDE7A (0.66) | PDE7ALMNAHCAR1PDE4APDE4B | |
| SCHEMBL290341 | 0.76 | PDE7A (0.71) | ALDH1A1PDE7ALMNASMN1; SMN2PDE4A | |
| SCHEMBL5440785 | 0.76 | ALDH1A1 (0.63) | ALDH1A1PDE7AALOX12MDM2LMNA | |
| SCHEMBL4207211 | 0.74 | PDE7A (0.58) | ALDH1A1PDE7ALMNAPTGS2KMT2A | |
| SCHEMBL1101917 | 0.74 | LMNA (0.72) | ALDH1A1PDE7ALMNASMN1; SMN2PDE4A | |
| SCHEMBL16204870 | 0.73 | KMT2A (0.58) | LMNASMN1; SMN2RAB9AKMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |