Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 4/20 | 0.33 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | OGT | O15294 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10780521 | 0.81 | GRM5 (0.38) | GRM5KMOMCL1GPR35NOS1 | |
| SCHEMBL11040536 | 0.78 | NOS1 (0.49) | GRM5KMOMCL1NOS1NOS3 | |
| SCHEMBL18107837 | 0.78 | GRM5 (0.37) | GRM5KMOMCL1NOS1NOS3 | |
| SCHEMBL15319641 | 0.78 | KMO (0.47) | GRM5KMOMCL1NOS1NOS3 | |
| SCHEMBL1285298 | 0.78 | NOS1 (0.41) | GRM5KMOMCL1NOS1NOS3 | |
| SCHEMBL11040319 | 0.76 | KMO (0.34) | KMOMCL1NOS1NOS3NOS2 | |
| SCHEMBL18188179 | 0.74 | GAA (0.41) | GRM5KMOMCL1NOS1NOS3 | |
| SCHEMBL11282616 | 0.74 | MCL1 (0.33) | KMOMCL1NOS1NOS3NOS2 | |
| SCHEMBL9954720 | 0.73 | GPR35 (0.40) | GRM5GPR35LMNACYP1A2TSHR | |
| SCHEMBL11040962 | 0.70 | NOS1 (0.32) | KMOMCL1NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |