Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31187915 | 1.00 | ACE2 (0.67) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20506761 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20835139 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL6760264 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL21086628 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20506755 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20506756 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20506759 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL20506768 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB | |
| SCHEMBL22129693 | 0.97 | ACE2 (0.62) | ACE2OPRM1LMNATSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230099694-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-03-30 | — | — | US | disclosed |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-02-25 | — | — | US | disclosed |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-02-27 | — | — | US | disclosed |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-20180318294-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-11-08 | — | — | US | disclosed |
| US-20180092907-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-05 | — | — | US | disclosed |
| EP-2151233-B1 | TWO-COMPONENT OXIDATIVE HAIR DYE COMPOSITION | KAO CORP (JP) | 2017-08-09 | — | — | EP | disclosed |
| EP-2151232-B1 | OXIDATIVE HAIR DYE COMPOSITION | KAO CORP (JP) | 2017-04-12 | — | — | EP | disclosed |
| US-20170071933-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-03-16 | — | — | US | disclosed |
| EP-2753617-B9 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMA CO LTD (JP) | 2017-01-25 | — | — | EP | disclosed |
| EP-1468665-A2 | Hair cosmetic composition | Kao Corporation (JP) | 2004-10-20 | — | — | EP | disclosed |
| US-20040166084-A1 | Hair cosmetic composition | KAO CORPORATION (JP) | 2004-08-26 | — | — | US | disclosed |
| US-20040156815-A1 | Hair cleansing composition | KAO CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| US-20040157984-A1 | Hair cleansing composition | KAO CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| EP-1433465-A2 | Hair cosmetic composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-1433464-A2 | Hair cleansing composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-1433466-A2 | Hair cleansing composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| US-20040115162-A1 | Dermatological preparations | KAO CORPORATION (JP) | 2004-06-17 | — | — | US | disclosed |
| US-6685953-B1 | WATER RETENTION CAPACITY; MOISTURIZER; ALKOXYALKYAMIDES OF ALKYLENEDICARBOXYLIC ACIDS | KAO CORPORATION (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-1166766-A1 | EXTERNAL PREPARATION COMPOSITIONS | Kao Corporation (JP) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230099694-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20170071933-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20180318294-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, SULT2A1, CYP4Z1 | ACE2 3451/4885OPRM1 1043/4885LMNA 4301/4885 |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20040166084-A1 | Hair cosmetic composition | H1-0, H1-2, SHH | ACE2 4356/4885OPRM1 1566/4885LMNA 680/4885 |
| US-20180092907-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | ACE2 3755/4885OPRM1 1578/4885LMNA 4438/4885 |
| US-20040156815-A1 | Hair cleansing composition | CUTA, TRPA1, SHH | ACE2 4001/4885OPRM1 3604/4885LMNA 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.