Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955323 | 0.80 | ESR2 (0.44) | NOTUMPGRESR2SMN1; SMN2TP53 | |
| SCHEMBL9956316 | 0.78 | NOTUM (0.37) | NOTUMTAAR1ESR2SMN1; SMN2L3MBTL1 | |
| SCHEMBL9955303 | 0.77 | ADORA2A (0.41) | NOTUMACHEMGAMGAASI | |
| SCHEMBL9955132 | 0.76 | L3MBTL1 (0.41) | NOTUMTAAR1ESR2L3MBTL1TP53 | |
| SCHEMBL9955412 | 0.71 | NOTUM (0.47) | NOTUMACHEMGAMGAASI | |
| SCHEMBL5543913 | 0.71 | TRPM8 (0.43) | NOTUMACHEMGAMGAASI | |
| SCHEMBL14923166 | 0.71 | SMN1; SMN2 (0.46) | NOTUMACHESMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL9956338 | 0.70 | NPC1 (0.39) | NOTUMACHEMGAMGAASI | |
| SCHEMBL13959846 | 0.69 | SMN1; SMN2 (0.44) | NOTUMTAAR1SMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL9955368 | 0.69 | KDM4E (0.41) | NOTUMACHEMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655363-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION | Bial-Portela & CA, S.A. (PT) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087174-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION | BIAL - PORTELA & Cª., S.A. (PT) | 2012-06-28 | — | — | WO | claimed |
| EP-2655363-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION | Bial-Portela & CA, S.A. (PT) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087174-A2 | CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION | BIAL - PORTELA & Cª., S.A. (PT) | 2012-06-28 | — | — | WO | disclosed |