Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.76 |
| ▸ | MAOB | P27338 | 3/20 | 0.76 |
| ▸ | GRM5 | P41594 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025790 | 0.87 | ALDH1A1 (0.80) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL10025785 | 0.87 | MAOA (1.00) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL23657014 | 0.81 | GRM5 (0.95) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL9955702 | 0.81 | GRM5 (1.00) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL9955883 | 0.81 | RAB9A (0.78) | MAOBGRM5ALDH1A1RAB9ANPC1 | |
| SCHEMBL9955400 | 0.80 | GRM5 (1.00) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL9957176 | 0.77 | MAOA (0.80) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL9955038 | 0.77 | GRM5 (1.00) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL10025786 | 0.75 | ALDH1A1 (0.62) | MAOAMAOBGRM5ALDH1A1RAB9A | |
| SCHEMBL10025789 | 0.72 | MAOA (0.70) | MAOAMAOBGRM5ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |