Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955861 | 0.83 | NR4A2 (0.41) | ALDH1A1HSD17B10SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9722805 | 0.79 | NR4A2 (0.47) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL11133573 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL11085745 | 0.73 | MAOA (0.44) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL11363260 | 0.71 | HSP90AB1 (0.49) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL11517352 | 0.69 | SMN1; SMN2 (0.52) | ALDH1A1HPGDHTTHSD17B10MAPK1 | |
| SCHEMBL11554054 | 0.68 | HRH4 (0.53) | ALDH1A1HSD17B10KDM4EPOLBPKM | |
| SCHEMBL31634411 | 0.67 | BCKDK (0.38) | ALDH1A1HTTKDM4ESMN1; SMN2MAPT | |
| SCHEMBL14549380 | 0.67 | POLB (0.47) | ALDH1A1HPGDHTTHSD17B10KDM4E | |
| SCHEMBL2729225 | 0.65 | PTPN11 (0.54) | ALDH1A1HPGDHTTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| US-4152518-A | ANTIINFLAMMATORY AGENTS | STERLING DRUG INC. (US) | 1979-05-01 | — | — | US | disclosed |
| US-4112105-A | Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles | STERLING DRUG INC. (US) | 1978-09-05 | — | — | US | disclosed |