Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13728019 | 0.88 | MAPT (0.48) | LMNANLRP3KAT2BHTTPOLB | |
| SCHEMBL2798845 | 0.85 | LMNA (0.52) | LMNANLRP3GLAKAT2BHTT | |
| SCHEMBL9956111 | 0.85 | LMNA (0.55) | LMNANLRP3GLAHTTPOLB | |
| SCHEMBL1346377 | 0.80 | LMNA (0.52) | LMNANLRP3GLAPOLBMAPT | |
| SCHEMBL982086 | 0.79 | KAT2B (0.48) | LMNAKAT2BHTTPOLBMAPT | |
| SCHEMBL2133106 | 0.79 | KMT2A (0.40) | LMNANLRP3KAT2BHTTPOLB | |
| SCHEMBL9694220 | 0.78 | LMNA (0.53) | LMNAGLAPOLBMAPTKDM4E | |
| SCHEMBL8435166 | 0.77 | PLK1 (0.51) | LMNANLRP3HTTPOLBMAPT | |
| SCHEMBL4296586 | 0.77 | NLRP3 (0.47) | LMNANLRP3HTTMAPTMEN1 | |
| SCHEMBL8190013 | 0.76 | LMNA (0.64) | LMNAGLAHTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |