Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13921287 | 0.81 | PLK1 (0.59) | PLK1PLK3HTTALDH1A1PTPN1 | |
| SCHEMBL9955508 | 0.77 | LMNA (0.52) | NLRP3HTTALDH1A1POLBLMNA | |
| SCHEMBL9573900 | 0.77 | CA12 (0.50) | NLRP3HTTALDH1A1POLBLMNA | |
| SCHEMBL31518574 | 0.77 | KDM4E (0.58) | PLK1ALDH1A1POLBPPIDLMNA | |
| SCHEMBL23645663 | 0.75 | NLRP3 (0.47) | NLRP3ALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL9573834 | 0.75 | SMN1; SMN2 (0.44) | PLK1HTTALDH1A1LMNAKDM4E | |
| SCHEMBL9573843 | 0.75 | CA12 (0.47) | NLRP3HTTALDH1A1POLBPPID | |
| SCHEMBL28668318 | 0.74 | ALDH1A1 (0.48) | NLRP3ALDH1A1PPIDLMNAKDM4E | |
| SCHEMBL1931504 | 0.74 | NLRP3 (0.55) | NLRP3ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5786263 | 0.74 | GAA (0.54) | NLRP3HTTALDH1A1POLBPPID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0847392-B1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | disclosed |
| CN-1194639-A | Quinazoline derivatives and their use as anti-inflammatory agents | CORIEN CO LTD (DE) | 1998-09-30 | — | — | CN | disclosed |
| EP-0847392-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | Clariant GmbH (DE) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997008154-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1997-03-06 | — | — | WO | disclosed |