Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956376 | 0.85 | HSD17B10 (0.42) | ALDH1A1HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL5518084 | 0.79 | HSD17B10 (0.46) | ALDH1A1HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL16417100 | 0.71 | NOTUM (0.50) | LMNAHCAR2 | |
| SCHEMBL15570393 | 0.71 | HCAR2 (0.40) | ALDH1A1HSD17B10LMNAHCAR2MAPT | |
| SCHEMBL13173703 | 0.70 | ALDH1A1 (0.50) | ALDH1A1HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL9957167 | 0.69 | HSD17B10 (0.43) | ALDH1A1HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL11584471 | 0.68 | ALDH1A1 (0.52) | ALDH1A1HSD17B10LMNANPSR1HPGD | |
| SCHEMBL5612429 | 0.66 | HCAR2 (0.40) | ALDH1A1HSD17B10LMNAHCAR2 | |
| SCHEMBL11645948 | 0.66 | HSD17B10 (0.72) | ALDH1A1HSD17B10LMNAMAPTNPSR1 | |
| SCHEMBL8207134 | 0.66 | HCAR2 (0.37) | ALDH1A1HSD17B10LMNAHCAR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |