Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154627 | 0.77 | MAPT (1.00) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL5612700 | 0.75 | MAPT (0.70) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL9240267 | 0.73 | ALDH1A1 (0.36) | MAPTALDH1A1KMT2AGAA | |
| SCHEMBL26724015 | 0.73 | CA1 (0.39) | MAPTALDH1A1KMT2AGAA | |
| SCHEMBL9956733 | 0.71 | CRBN (0.36) | — | |
| SCHEMBL9955837 | 0.68 | MAPT (0.31) | MAPT | |
| SCHEMBL10794719 | 0.68 | MAPT (0.59) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL1219343 | 0.68 | MAPT (0.59) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL3666632 | 0.67 | MAPT (0.57) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL7672914 | 0.67 | MAPT (0.57) | MAPTALDH1A1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |