Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 6/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161915 | 0.75 | MAPT (0.48) | CRBN | |
| SCHEMBL26724015 | 0.74 | CA1 (0.39) | HTR2AHRH1METAP1 | |
| SCHEMBL9240267 | 0.74 | ALDH1A1 (0.36) | HTR2AHRH1METAP1 | |
| SCHEMBL6869112 | 0.72 | METAP1 (0.39) | METAP1 | |
| SCHEMBL9955958 | 0.71 | MAPT (0.61) | — | |
| SCHEMBL11431438 | 0.67 | ALDH1A1 (0.41) | CRBN | |
| SCHEMBL7079188 | 0.66 | CRBN (0.48) | CRBN | |
| SCHEMBL5199186 | 0.63 | TLR4 (0.41) | METAP1 | |
| SCHEMBL1705495 | 0.62 | CRBN (0.43) | CRBNCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1177125 | 0.62 | CRBN (0.43) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |