Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP1 | P63208 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957734 | 1.00 | RET (0.42) | RETMAP4K4GPR119USP30SPR | |
| SCHEMBL9957065 | 0.86 | RET (0.46) | RETMAP4K4GPR119USP30NR1H2 | |
| SCHEMBL9957068 | 0.86 | RET (0.46) | RETMAP4K4GPR119USP30NR1H2 | |
| SCHEMBL9956636 | 0.86 | DPP4 (0.38) | — | |
| SCHEMBL9957283 | 0.83 | GPR119 (0.50) | RETGPR119CKS1BSKP1SKP2 | |
| SCHEMBL9957280 | 0.83 | GPR119 (0.50) | RETGPR119CKS1BSKP1SKP2 | |
| SCHEMBL9956083 | 0.78 | DPP4 (0.38) | MAP4K4 | |
| SCHEMBL9957393 | 0.75 | HCRTR1 (0.57) | — | |
| SCHEMBL9957415 | 0.75 | HCRTR1 (0.45) | — | |
| SCHEMBL9957807 | 0.74 | HCRTR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |