Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 10/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959855 | 0.81 | HTR1A (0.56) | HTR1ASLC6A2SLC6A3DRD2HTR2A | |
| SCHEMBL9955994 | 0.72 | MAOB (0.53) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL9954948 | 0.71 | KDM4E (0.48) | HTR1ADRD2HTR2AHTR1DHTR1B | |
| SCHEMBL9954861 | 0.70 | ALDH1A1 (0.47) | DRD2DRD3 | |
| SCHEMBL10068249 | 0.66 | BACE1 (0.57) | — | |
| SCHEMBL932198 | 0.62 | — | — | |
| SCHEMBL9051496 | 0.62 | NPSR1 (0.51) | HTR1ADRD2HTR1DHTR1BDRD3 | |
| SCHEMBL428483 | 0.61 | HTR1A (0.73) | HTR1ASLC6A4HTR1DHTR1BKCNH2 | |
| SCHEMBL6219096 | 0.61 | HTR2A (0.58) | HTR1ADRD2HTR2A | |
| SCHEMBL21485179 | 0.61 | DRD2 (1.00) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655365-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | claimed |