Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28276689 | 0.85 | HTR5A (0.47) | KDM4EALDH1A1BACE1HTR5AHTR6 | |
| SCHEMBL27924388 | 0.85 | HTR5A (0.47) | KDM4EALDH1A1BACE1HTR5AHTR6 | |
| SCHEMBL9954861 | 0.84 | ALDH1A1 (0.47) | KDM4EALDH1A1NPC1RAB9ABACE1 | |
| SCHEMBL9955994 | 0.81 | MAOB (0.53) | KDM4EALDH1A1NPC1RAB9ABACE1 | |
| SCHEMBL29174566 | 0.80 | MAOB (0.45) | KDM4EALDH1A1HTR1AHTR2ADRD2 | |
| SCHEMBL30725472 | 0.80 | MAOB (0.45) | KDM4EALDH1A1HTR1AHTR2ADRD2 | |
| SCHEMBL10068249 | 0.80 | BACE1 (0.57) | KDM4EALDH1A1NPC1RAB9ABACE1 | |
| Hydrochloric Acid SCHEMBL28059090 | 0.76 | HTR6 (0.40) | KDM4EALDH1A1NPC1RAB9AHTR5A | |
| SCHEMBL8805531 | 0.74 | NPC1 (0.46) | KDM4EALDH1A1NPC1RAB9AHTR5A | |
| SCHEMBL6017110 | 0.73 | HTR1A (0.56) | KDM4EALDH1A1HTR5AHTR6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | claimed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | claimed |
| EP-2655365-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | claimed |
| CN-103380129-A | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB | 2013-10-30 | — | — | CN | claimed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | claimed |
| EP-2655365-B1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | Acturum Life Science AB (SE) | 2015-12-16 | — | — | EP | disclosed |
| EP-2655365-B1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | Acturum Life Science AB (SE) | 2015-12-16 | — | — | EP | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| EP-2655365-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | GRIN2C, BDNF, GRIN2A | KDM4E 1126/4885ALDH1A1 436/4885NPC1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.