Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9644950 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL9643726 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL9642764 | 0.73 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL19256889 | 0.72 | PTGS1 (0.35) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL257133 | 0.71 | NOS1 (0.39) | KDM4EMAPTHSD17B10 | |
| SCHEMBL3344131 | 0.71 | CNR1 (0.47) | ALDH1A1HPGDMAPTTSHRLMNA | |
| SCHEMBL26686993 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDTSHRNPC1 | |
| SCHEMBL4769266 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL9643711 | 0.70 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL2267607 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |