Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tazarotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 10/20 | 0.81 |
| ▸ | RARG known ✓ | P13631 | 10/20 | 0.81 |
| ▸ | RARA known ✓ | P10276 | 9/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.81 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.73 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotene SCHEMBL28326300 | 0.93 | RARA (0.80) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL995330 | 0.93 | RARB (0.88) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL3134 | 0.90 | RARA (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL5747908 | 0.90 | RARA (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL29512592 | 0.90 | RARA (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL29397163 | 0.90 | RARA (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotene SCHEMBL6101987 | 0.89 | RARA (0.98) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotenic Acid SCHEMBL678713 | 0.86 | CYP3A4 (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotenic Acid SCHEMBL29466098 | 0.86 | CYP3A4 (1.00) | RARBRARGRARAKMT2ACYP3A4 | |
| Tazarotenic Acid SCHEMBL29433140 | 0.86 | CYP3A4 (1.00) | RARBRARGRARAKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357669-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. | 2014-12-04 | — | — | US | claimed |
| US-9062037-B2 | Tazarotene derivatives | STIEFEL LABORATORIES, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140357672-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. | 2014-12-04 | — | — | US | disclosed |
| US-20140357669-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. | 2014-12-04 | — | — | US | disclosed |
| CN-102595892-B | Tazarotene derivatives | STIEFEL LABORATORIES | 2014-09-10 | — | — | CN | disclosed |
| CN-102595892-A | Tazarotene derivatives | STIEFEL LABORATORIES | 2012-07-18 | — | — | CN | disclosed |
| EP-2453746-A1 | TAZAROTENE DERIVATIVES | Stiefel Laboratories, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| US-20120115909-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. | 2012-05-10 | — | — | US | disclosed |
| WO-2011009023-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357672-A1 | TAZAROTENE DERIVATIVES | RXRA, RARA, RXRB | RARB 5/4885RARG 6/4885RARA 2/4885 |
| US-20140357669-A1 | TAZAROTENE DERIVATIVES | RXRA, RARA, RXRB | RARB 5/4885RARG 6/4885RARA 2/4885 |
| US-20120115909-A1 | TAZAROTENE DERIVATIVES | RXRA, RARA, RXRB | RARB 5/4885RARG 6/4885RARA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.