Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958538 | 0.83 | TDP2 (0.46) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL18543791 | 0.79 | TDP2 (0.36) | BACE1TDP2CMA1AHRMETAP1 | |
| SCHEMBL24275671 | 0.77 | TDP2 (0.41) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL9958457 | 0.75 | TDP2 (0.41) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL30726 | 0.75 | BACE1 (0.43) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL19566706 | 0.75 | BACE1 (0.48) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL18926423 | 0.75 | BACE1 (0.42) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL12533714 | 0.74 | ASIC3 (0.44) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL9958466 | 0.73 | BACE1 (0.40) | BACE1TDP2CMA1AHRAPP | |
| SCHEMBL31076 | 0.73 | BACE1 (0.40) | BACE1TDP2CMA1AHRAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655378-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087237-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |