Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 2/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959281 | 0.83 | BACE1 (0.40) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL18543791 | 0.81 | TDP2 (0.36) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL11073635 | 0.80 | TDP2 (0.47) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL9958457 | 0.79 | TDP2 (0.41) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL30493 | 0.78 | TDP2 (0.39) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL9958466 | 0.77 | BACE1 (0.40) | TDP2CMA1AHRMETAP1PNMT | |
| SCHEMBL31076 | 0.77 | BACE1 (0.40) | TDP2CMA1AHRMETAP1PNMT | |
| SCHEMBL30649 | 0.76 | TDP2 (0.37) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL24275671 | 0.76 | TDP2 (0.41) | TDP2CMA1AHRMETAP1BRD4 | |
| SCHEMBL30690 | 0.75 | TDP2 (0.40) | TDP2CMA1AHRMETAP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655378-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087237-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |