Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5609778 | 0.86 | CYP11B1 (0.49) | CA12CA9NR1I2CYP11B1CYP11B2 | |
| SCHEMBL7856927 | 0.84 | NAPRT (0.46) | CYP11B1CYP11B2NAPRTHTTSMN1; SMN2 | |
| SCHEMBL10211749 | 0.83 | ALDH1A1 (0.52) | CA12CA9CYP11B1CYP11B2NAPRT | |
| SCHEMBL5610078 | 0.82 | CYP11B1 (0.44) | CA12CA9NR1I2CYP11B1CYP11B2 | |
| SCHEMBL812702 | 0.82 | CA12 (0.78) | CA12CA9NR1I2LMNAHTT | |
| SCHEMBL670866 | 0.80 | NAPRT (0.57) | NAPRTLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL30498935 | 0.80 | NAPRT (0.57) | NAPRTLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL10169398 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2NAPRTNR1H3L3MBTL1 | |
| SCHEMBL9954268 | 0.80 | KEAP1 (0.48) | CYP11B1CYP11B2NAPRTKEAP1NFE2L2 | |
| SCHEMBL2568384 | 0.80 | SMN1; SMN2 (0.62) | NR1I2LMNASMN1; SMN2TSHRNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |