Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960452 | 0.89 | KCNA5 (0.46) | KCNA5MEN1KMT2AMAPTKCNH2 | |
| SCHEMBL10153741 | 0.87 | ALDH1A1 (0.38) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL9959297 | 0.82 | HDAC4 (0.49) | KCNA5MEN1KMT2AMAPTFFAR1 | |
| SCHEMBL10153637 | 0.80 | KCNA5 (0.42) | KCNA5MEN1KMT2AMAPTTSHR | |
| SCHEMBL9959313 | 0.80 | KCNA5 (0.48) | KCNA5MEN1KMT2AMAPTPOLB | |
| SCHEMBL9958850 | 0.80 | MEN1 (0.43) | KCNA5MEN1KMT2AMAPTFFAR1 | |
| SCHEMBL10153642 | 0.79 | KCNA5 (0.42) | KCNA5MEN1KMT2AMAPTFFAR1 | |
| SCHEMBL9958887 | 0.79 | PSEN1 (0.38) | KCNA5MEN1KMT2AMAPTFFAR1 | |
| SCHEMBL11787179 | 0.79 | MEN1 (0.47) | MEN1KMT2AMAPTFFAR1TSHR | |
| SCHEMBL10153971 | 0.78 | POLB (0.50) | KCNA5MEN1KMT2AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |