Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.59 |
| ▸ | CTSS | P25774 | 5/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9962153 | 0.87 | CASP3 (0.59) | CTSKCTSSCASP3CTSDCTSB | |
| SCHEMBL5557360 | 0.85 | CTSS (0.66) | CTSKCTSSCASP3CTSDMMP9 | |
| SCHEMBL16770356 | 0.83 | CASP3 (0.46) | CTSKCTSSCASP3CTSDMMP9 | |
| SCHEMBL7878105 | 0.82 | CTSD (0.44) | CTSKCTSSCASP3CTSDMMP9 | |
| SCHEMBL17137921 | 0.80 | CTSS (0.77) | CTSKCTSSMMP9MMP8MMP14 | |
| SCHEMBL17137918 | 0.80 | CTSS (0.77) | CTSKCTSSMMP9MMP8MMP14 | |
| SCHEMBL23771802 | 0.80 | CTSS (0.56) | CTSKCTSSCASP3CTSDCTSB | |
| SCHEMBL9962288 | 0.80 | CASP3 (0.60) | CTSKCASP3CTSDCTSBCTSL | |
| SCHEMBL16459632 | 0.79 | CTSS (0.66) | CTSKCTSSMMP9MMP8MMP14 | |
| SCHEMBL16459631 | 0.79 | CTSS (0.66) | CTSKCTSSMMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045524-B2 | Selective caspase inhibitors and uses thereof | NOVAGENESIS FOUNDATION (CH) | 2015-06-02 | — | — | US | disclosed |
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | NEW WORLD LABORATORIES, INC. (CA) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | CASP1, VIP, CASP5 | CTSK 90/4885CTSS 73/4885CASP3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.