Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.36 |
| ▸ | NCS1 | P62166 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963498 | 0.79 | TOP2A (0.46) | TOP2ACSNK1DDYRK1AALDH1A1LMNA | |
| SCHEMBL9963605 | 0.74 | PTGS2 (0.45) | TOP2ADYRK1APTGS2PKMSMN1; SMN2 | |
| SCHEMBL9963493 | 0.68 | GAA (0.39) | TOP2APTGS2PKMALDH1A1LMNA | |
| SCHEMBL9963603 | 0.67 | PTGS2 (0.53) | TOP2APTGS2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9963491 | 0.67 | RAB9A (0.37) | TOP2ADYRK1APTGS2PKMALDH1A1 | |
| SCHEMBL9963517 | 0.66 | GAA (0.41) | TOP2ADYRK1APTGS2PKMALDH1A1 | |
| SCHEMBL9963502 | 0.65 | TMPRSS15 (0.56) | TOP2ADYRK1ASMN1; SMN2 | |
| SCHEMBL9963615 | 0.64 | PTGS2 (0.43) | TOP2APTGS2PKMALDH1A1LMNA | |
| SCHEMBL9928638 | 0.63 | ALDH1A1 (0.48) | TOP2APTGS2PKMALDH1A1LMNA | |
| SCHEMBL15943687 | 0.63 | SMN1; SMN2 (0.49) | PKMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032583-B1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |
| US-8203001-B2 | Chemical compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-19 | — | — | US | disclosed |
| US-8203001-B2 | Chemical compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20090258857-A1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
| US-20090258857-A1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
| WO-2007144370-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258857-A1 | CHEMICAL COMPOUNDS | CCNA1, CCNT1, MKI67 | TOP2A 772/4885CSNK1D 402/4885NCS1 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.