Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965475 | 0.83 | F10 (0.53) | POLBUBE2MDCUN1D1RXFP1TACR1 | |
| SCHEMBL9965458 | 0.81 | TP53 (0.49) | POLBTRPV1HDAC3HDAC1HDAC2 | |
| SCHEMBL9965416 | 0.79 | GAA (0.57) | POLBEPHX2TRPV1UBE2MDCUN1D1 | |
| SCHEMBL9965417 | 0.72 | EPHX2 (0.57) | POLBEPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL2892697 | 0.72 | KDM4E (0.55) | POLBHDAC3HDAC1HDAC2MAPK8 | |
| SCHEMBL13735120 | 0.72 | HDAC1 (0.65) | POLBHDAC3HDAC1HDAC2MAPK8 | |
| SCHEMBL9965372 | 0.71 | GAA (0.55) | POLBEPHX2TRPV1UBE2MDCUN1D1 | |
| SCHEMBL18658132 | 0.71 | MAPT (0.57) | POLBHDAC3HDAC1HDAC2MAPT | |
| SCHEMBL9965449 | 0.70 | KDM4E (0.51) | EPHX2UBE2MDCUN1D1MAPTTSHR | |
| SCHEMBL9965450 | 0.70 | ALDH1A1 (0.68) | HDAC3HDAC1HDAC2MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-B1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | STERIX LTD (GB) | 2012-06-20 | — | — | EP | disclosed |