Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965406 | 0.84 | TRPV1 (0.51) | TP53GAAMAPTPOLBTRPV1 | |
| SCHEMBL14639698 | 0.83 | TDP1 (0.46) | TP53GAAMAPTPOLBTRPV1 | |
| SCHEMBL9965381 | 0.81 | POLB (0.53) | MAPTPOLBMAPK8MAPK10TRPV1 | |
| SCHEMBL642196 | 0.78 | GAA (0.56) | TP53GAAPOLBMAPK8MAPK10 | |
| SCHEMBL14639718 | 0.76 | GAA (0.48) | TP53GAAMAPTPOLBTRPV1 | |
| SCHEMBL13028221 | 0.74 | GAA (0.48) | TP53GAAMAPTPOLBHDAC3 | |
| SCHEMBL9965449 | 0.74 | KDM4E (0.51) | MAPTCCR3 | |
| SCHEMBL13735120 | 0.74 | HDAC1 (0.65) | TP53POLBMAPK8MAPK10HDAC3 | |
| SCHEMBL2892697 | 0.74 | KDM4E (0.55) | TP53POLBMAPK8MAPK10HDAC3 | |
| SCHEMBL9965417 | 0.74 | EPHX2 (0.57) | TP53MAPTPOLBMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-B1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | STERIX LTD (GB) | 2012-06-20 | — | — | EP | disclosed |