Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948029 | 0.87 | KDM4E (0.40) | GPR119NR1H2NAMPTUSP2SMN1; SMN2 | |
| SCHEMBL9933338 | 0.81 | KDM5A (0.36) | — | |
| SCHEMBL9933335 | 0.81 | KDM5A (0.36) | — | |
| SCHEMBL14683780 | 0.80 | HPGDS (0.48) | GPR119USP30SMN1; SMN2 | |
| SCHEMBL9965957 | 0.79 | KDM5A (0.48) | JAK3SSTR4GPR119NR1H2NAMPT | |
| SCHEMBL12835643 | 0.79 | KDM5A (0.48) | JAK3SSTR4GPR119NR1H2NAMPT | |
| SCHEMBL16182224 | 0.79 | KDM5A (0.48) | JAK3SSTR4GPR119NR1H2NAMPT | |
| SCHEMBL16182182 | 0.78 | JAK3 (0.41) | JAK3SSTR4GPR119NR1H2USP30 | |
| SCHEMBL9965898 | 0.78 | JAK3 (0.41) | JAK3SSTR4GPR119NR1H2USP30 | |
| SCHEMBL12835914 | 0.78 | JAK3 (0.41) | JAK3SSTR4GPR119NR1H2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157432-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME, CORP. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157432-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | JAK3 788/4885SSTR4 462/4885GPR119 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.