Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9966385 | 0.82 | MAP4K4 (0.44) | MAP4K4CYP2C9HDAC1 | |
| SCHEMBL9966458 | 0.79 | GSK3B (0.46) | MAP4K4ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL9966457 | 0.73 | RIPK1 (0.40) | MAP4K4POLBCHEK2MKNK1MKNK2 | |
| SCHEMBL9966366 | 0.72 | MAP4K4 (0.46) | MAP4K4ALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL9966514 | 0.72 | MAP4K4 (0.40) | MAP4K4ALDH1A1HDAC1 | |
| SCHEMBL9966389 | 0.70 | ALOX5 (0.41) | MAP4K4ALDH1A1MEN1KMT2AHDAC1 | |
| SCHEMBL14295962 | 0.70 | MAP4K4 (0.50) | MAP4K4ALDH1A1CYP2C9KMT2AHDAC1 | |
| SCHEMBL9966380 | 0.69 | PIK3CA (0.33) | MAP4K4ALDH1A1HDAC1 | |
| SCHEMBL9936397 | 0.68 | MAP4K4 (0.47) | MAP4K4CYP2C9HDAC1 | |
| SCHEMBL9966360 | 0.68 | GSK3B (0.50) | MAP4K4ALDH1A1POLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082817-A1 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |