Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | P4HB | P07237 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18242242 | 0.81 | NFE2L2 (0.54) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL9967782 | 0.81 | NFE2L2 (0.37) | NFE2L2FBP1MAPT | |
| SCHEMBL30620000 | 0.79 | NFE2L2 (0.66) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL2787109 | 0.79 | NFE2L2 (0.66) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL2662410 | 0.79 | NFE2L2 (0.66) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL11437739 | 0.79 | NFE2L2 (0.66) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL13790316 | 0.79 | NFE2L2 (0.82) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL29018208 | 0.79 | NFE2L2 (0.49) | NFE2L2FBP1MAOBP4HBMEN1 | |
| SCHEMBL9967779 | 0.78 | MAPT (0.46) | NFE2L2MEN1LMNAMAPTKMT2A | |
| SCHEMBL18608302 | 0.78 | NFE2L2 (0.69) | NFE2L2FBP1MAOBP4HBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER IP GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER IP GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| US-9006265-B2 | Substituted fused pyrimidinones and dihydropyrimidinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006265-B2 | Substituted fused pyrimidinones and dihydropyrimidinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |
| US-7250533-B2 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2007-07-31 | — | — | US | disclosed |
| US-20070043243-A1 | Process for preparing Cinacalcet hydrochloride | TEVA PHARMACEUTICALS USA, INC. | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | DHPS, FDPS, DPYD | NFE2L2 255/4885FBP1 108/4885MAOB 1900/4885 |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | DHPS, FDPS, DPYD | NFE2L2 255/4885FBP1 108/4885MAOB 1900/4885 |
| US-20070043243-A1 | Process for preparing Cinacalcet hydrochloride | SI, PRCP, CA9 | NFE2L2 4160/4885FBP1 2546/4885MAOB 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.