Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932110 | 0.91 | HSD11B1 (0.48) | HSD11B1SMN1; SMN2METAP2METAP1KDR | |
| SCHEMBL9968414 | 0.84 | HSD11B1 (0.47) | HSD11B1SMN1; SMN2CA1CA2KMT2A | |
| SCHEMBL9968321 | 0.82 | HSD11B1 (0.47) | HSD11B1SMN1; SMN2CA1CA2KMT2A | |
| SCHEMBL12841343 | 0.80 | METAP2 (0.44) | HSD11B1SMN1; SMN2METAP2METAP1KDR | |
| SCHEMBL9968417 | 0.80 | METAP2 (0.44) | SMN1; SMN2METAP2METAP1KDRPTK2 | |
| SCHEMBL9932520 | 0.80 | MEN1 (0.48) | SMN1; SMN2METAP2METAP1KDRPTK2 | |
| SCHEMBL1533907 | 0.79 | HTR3A (0.49) | METAP2METAP1KDRPTK2KMT2A | |
| SCHEMBL9968297 | 0.77 | SMO (0.50) | HSD11B1SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL9931983 | 0.77 | KMT2A (0.46) | SMN1; SMN2METAP2METAP1KDRPTK2 | |
| SCHEMBL9931365 | 0.77 | ALDH1A1 (0.48) | SMN1; SMN2METAP2METAP1KDRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | HSD11B1 3610/4885SMN1; SMN2 1175/4885METAP2 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.