Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | RRM1 | P23921 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 4/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24181000 | 1.00 | DPP7 (0.46) | DPP7ANPEPERAP2RRM1ALDH1A1 | |
| SCHEMBL12367218 | 0.94 | ANPEP (0.40) | DPP7ANPEPERAP2RRM1ALDH1A1 | |
| SCHEMBL9705885 | 0.87 | GNAI3 (0.50) | ANPEPERAP2RRM1ALDH1A1TSHR | |
| SCHEMBL22615112 | 0.86 | ANPEP (0.51) | ANPEPERAP2RRM1ALDH1A1TSHR | |
| SCHEMBL6825299 | 0.86 | GNAI3 (0.49) | ANPEPERAP2ALDH1A1TSHRGNAI3 | |
| SCHEMBL19921562 | 0.86 | TSHR (0.50) | DPP7ANPEPERAP2ALDH1A1TSHR | |
| SCHEMBL10382687 | 0.85 | SPHK1 (0.44) | ANPEPERAP2ALDH1A1TSHRGNAI3 | |
| SCHEMBL6553597 | 0.85 | FFAR4 (0.47) | ANPEPERAP2RRM1GNAI3GNAO1 | |
| SCHEMBL22615106 | 0.85 | ANPEP (0.50) | ANPEPERAP2ALDH1A1TSHRRELA | |
| SCHEMBL9705642 | 0.85 | FFAR4 (0.47) | ANPEPERAP2RRM1GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150202175-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | FARBER MICHAEL (US) | 2015-07-23 | — | — | US | disclosed |
| US-20150093338-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | FARBER MICHAEL (US) | 2015-04-02 | — | — | US | disclosed |
| US-8946160-B2 | Nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2015-02-03 | — | — | US | disclosed |
| US-8883844-B2 | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions | NITROGENIX INC. (VG) | 2014-11-11 | — | — | US | disclosed |
| US-20140148438-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NITROGENIX, INC. (VG) | 2014-05-29 | — | — | US | disclosed |
| US-20130287866-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2013-10-31 | — | — | US | disclosed |
| US-20120289597-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2012-11-15 | — | — | US | disclosed |
| WO-2012079146-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR IMPROVING VASCULAR CIRCULATION, AND PROPHYLAXIS OR TREATMENT OF A CONDITION ASSOCIATED WITH IMPAIRED BLOOD CIRCULATION | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012037665-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2012-03-29 | — | — | WO | disclosed |
| WO-2011057387-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | ORAL DELIVERY TECHNOLOGY LTD . (CA) | 2011-05-19 | — | — | WO | disclosed |
| US-20100311780-A1 | Nitric oxide amino acid ester compound, composition for increasing nitirc oxide levels and method of use | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2010-12-09 | — | — | US | disclosed |
| US-20100311780-A1 | Nitric oxide amino acid ester compound, composition for increasing nitirc oxide levels and method of use | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150202175-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | NOS1, NOS2, NOS3 | DPP7 2541/4885ANPEP 95/4885ERAP2 764/4885 |
| US-20130287866-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | NOS1, NOS2, NOS3 | DPP7 2099/4885ANPEP 143/4885ERAP2 947/4885 |
| US-20140148438-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NOS2, NOS1, NOS3 | DPP7 3313/4885ANPEP 28/4885ERAP2 856/4885 |
| US-20120289597-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | NOS2, NOS3, NOS1 | DPP7 1653/4885ANPEP 62/4885ERAP2 864/4885 |
| US-20150093338-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NOS2, NOS1, NOS3 | DPP7 3313/4885ANPEP 28/4885ERAP2 856/4885 |
| US-20100311780-A1 | Nitric oxide amino acid ester compound, composition for increasing nitirc oxide levels and method of use | NOS1, NOS2, NOS3 | DPP7 2234/4885ANPEP 57/4885ERAP2 1130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.