Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 3/20 | 0.52 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234772 | 0.81 | KCNA5 (0.60) | HRH3HRH2HRH1 | |
| SCHEMBL7135163 | 0.81 | LTA4H (0.81) | LTA4H | |
| SCHEMBL25538081 | 0.80 | HRH3 (0.63) | HRH3HRH2HRH1MAOB | |
| SCHEMBL7141718 | 0.80 | LTA4H (1.00) | LTA4H | |
| SCHEMBL21207945 | 0.80 | KMT2A (0.52) | HRH3KCNH2MEN1KMT2A | |
| SCHEMBL22639936 | 0.78 | SIGMAR1 (0.76) | HRH3KMT2AHRH2HRH1MAOB | |
| SCHEMBL25540765 | 0.77 | HRH3 (0.65) | HRH3HRH2HRH1 | |
| SCHEMBL20230970 | 0.77 | KCNA5 (0.59) | — | |
| SCHEMBL20230973 | 0.77 | HRH3 (0.54) | LTA4HHRH3 | |
| SCHEMBL3589168 | 0.76 | LTA4H (0.55) | LTA4HHRH3KCNH2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963276-B9 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2012-09-26 | — | — | EP | disclosed |
| EP-1963276-B1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2012-06-20 | — | — | EP | disclosed |