Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.58 |
| ▸ | ALPG | P10696 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22651884 | 0.90 | MEN1 (0.59) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL28065937 | 0.87 | CHRM2 (0.63) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL1102038 | 0.85 | CHRM2 (0.70) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL4700798 | 0.84 | ALDH1A1 (0.71) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL9664090 | 0.84 | CHRM2 (0.60) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL5859908 | 0.83 | ALDH1A1 (0.66) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL28643439 | 0.81 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL21515338 | 0.81 | CHRM2 (0.74) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL29930459 | 0.81 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL11671841 | 0.81 | ALPL (0.70) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238578-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-20 | — | — | US | disclosed |
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |
| US-20100221251-A1 | Compositions and Methods for Treatment of Cancer | ARQULE, INC. (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238578-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | SCNN1G, KCNN3, KCNN2 | CHRM2 1093/4885CHRM4 1075/4885CHRM1 1682/4885 |
| US-20100221251-A1 | Compositions and Methods for Treatment of Cancer | PDCD5, TP53, NUP205 | CHRM2 4536/4885CHRM4 4573/4885CHRM1 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.