Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 5/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31394338 | 0.76 | TDP1 (0.47) | LPLLIPGROCK1 | |
| SCHEMBL9937263 | 0.76 | GPR119 (0.51) | BACE1GPR119ROCK1 | |
| SCHEMBL9936940 | 0.76 | USP30 (0.49) | GPR119 | |
| SCHEMBL2595915 | 0.73 | PNMT (0.36) | RORCGPR119 | |
| SCHEMBL30051494 | 0.73 | LPL (0.36) | LPLLIPGBACE1ROCK1 | |
| SCHEMBL25208903 | 0.71 | LPL (0.37) | LPLLIPGROCK1 | |
| SCHEMBL4145472 | 0.71 | POLB (0.39) | LPLLIPGBACE1ROCK1 | |
| SCHEMBL2595236 | 0.70 | RORC (0.38) | RORCGPR119 | |
| SCHEMBL23564249 | 0.70 | HRH3 (0.38) | LPLLIPGBACE1ROCK1 | |
| SCHEMBL19585596 | 0.70 | ROCK1 (0.35) | LPLLIPGROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080476-A1 | FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |