Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974834 | 0.87 | KDM4E (0.47) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL20053346 | 0.81 | MAPT (0.41) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9974832 | 0.75 | KDM4E (0.49) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9974823 | 0.72 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDHTR3A | |
| SCHEMBL29574988 | 0.70 | ALDH1A1 (0.61) | POLBMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL25733860 | 0.70 | ALDH1A1 (0.61) | POLBMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28370067 | 0.69 | THRA (0.57) | POLBMAPTALDH1A1EGFRPTGS2 | |
| SCHEMBL7437043 | 0.69 | HTR3E (0.61) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9974831 | 0.69 | KDM4E (0.51) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL2834167 | 0.68 | ALDH1A1 (0.63) | POLBMAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080447-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |